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antibody against cox 2  (Proteintech)


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    Proteintech antibody against cox 2
    Therapeutic effect of LAC in the monoiodoacetate mouse model. (A) H&E staining of the joint from MIA mice after different treatments. (B) Quantitative analysis of the synovitis score. (C) Representative images of SO&FG‐stained knee joint sections from MIA mice with different treatments. (D) The severity of OA‐like lesions was analyzed using the OARSI scoring system. (E) Immunofluorescence imaging of iNOS (red)/CD206 (green) within the knee joints of mice with different treatments. (F) Corresponding quantification of the MFI of CD206 in the synovium of mice with different treatments. (G) Immunohistochemical staining of <t>COX‐2,</t> TNF‐α, and TRAP in the knee joints of mice with different treatments. (H,I) Quantification of the relative density of COX‐2 + (H) and TNF‐α + (I) cells in the knee joints of mice with different treatments. n = 5 in B and D, and n = 3 in F, H, and I, mean ± SD. The significant differences are determined by one‐way ANOVA analysis with Tukey's multiple comparison test. ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns stands for no significant difference.
    Antibody Against Cox 2, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1107 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti+cox2/COX2%2F+Cyclooxygenase+2%2F+PTGS2+Antibody/pmc13650196-305-42-46
    Average 96 stars, based on 1107 article reviews
    antibody against cox 2 - by Bioz Stars, 2026-10
    96/100 stars

    Images

    1) Product Images from "Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage"

    Article Title: Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage

    Journal: Exploration

    doi: 10.1002/exp2.70233

    Therapeutic effect of LAC in the monoiodoacetate mouse model. (A) H&E staining of the joint from MIA mice after different treatments. (B) Quantitative analysis of the synovitis score. (C) Representative images of SO&FG‐stained knee joint sections from MIA mice with different treatments. (D) The severity of OA‐like lesions was analyzed using the OARSI scoring system. (E) Immunofluorescence imaging of iNOS (red)/CD206 (green) within the knee joints of mice with different treatments. (F) Corresponding quantification of the MFI of CD206 in the synovium of mice with different treatments. (G) Immunohistochemical staining of COX‐2, TNF‐α, and TRAP in the knee joints of mice with different treatments. (H,I) Quantification of the relative density of COX‐2 + (H) and TNF‐α + (I) cells in the knee joints of mice with different treatments. n = 5 in B and D, and n = 3 in F, H, and I, mean ± SD. The significant differences are determined by one‐way ANOVA analysis with Tukey's multiple comparison test. ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns stands for no significant difference.
    Figure Legend Snippet: Therapeutic effect of LAC in the monoiodoacetate mouse model. (A) H&E staining of the joint from MIA mice after different treatments. (B) Quantitative analysis of the synovitis score. (C) Representative images of SO&FG‐stained knee joint sections from MIA mice with different treatments. (D) The severity of OA‐like lesions was analyzed using the OARSI scoring system. (E) Immunofluorescence imaging of iNOS (red)/CD206 (green) within the knee joints of mice with different treatments. (F) Corresponding quantification of the MFI of CD206 in the synovium of mice with different treatments. (G) Immunohistochemical staining of COX‐2, TNF‐α, and TRAP in the knee joints of mice with different treatments. (H,I) Quantification of the relative density of COX‐2 + (H) and TNF‐α + (I) cells in the knee joints of mice with different treatments. n = 5 in B and D, and n = 3 in F, H, and I, mean ± SD. The significant differences are determined by one‐way ANOVA analysis with Tukey's multiple comparison test. ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns stands for no significant difference.

    Techniques Used: Staining, Analysis, Immunofluorescence, Imaging, Immunohistochemical staining, Comparison

    Related Articles

    Western Blot:

    Article Title: Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis.
    Article Snippet: .. Proteins were resolved by SDS-PAGE, ransferred to polyvinylidene difluoride (PVDF) membranes and hen analyzed by immunoblot using primary antibodies includng anti-ACSL4 (1:1000, RM8098, Biodragon, Suzhou, China), nti-ATF6 (1:2000, 24169-1-AP, Proteintech, Illinois, USA), anti-actin (1:1000, 66009-1-Ig, Proteintech), anti-Bax (1:1000, 50599- -Ig, Proteintech), anti-Beclin (1:1000, 11306-1-AP, Selleck, Texas, SA), anti-BIP (1:500, 66574-1-Ig, Proteintech), anti-CAT (1:2000, AB1405562, Sigma–Aldrich, Missouri, USA), anti-COX2 (1:1000, M6051, Biodragon), anti-GAPDH (1:1000, 60004-1-Ig, Proteinech), anti-GPX4 (1:1000, 52455S, CST, Massachusetts, USA), anti53 (1:1000, 10442-1-AP, Proteintech), anti-p62 (1:1000, E1462, Seleck), anti-SLC7A11 (1:1000, 26864-1-AP, CST), anti-SOD1 (1:1000, b308181, Abcam), anti-StAR (1:1000, 67130-1-Ig, Proteintech), ndrology, 2026 anti-Vinculin (1:1000, 13901S, CST), and anti-XBP1S (1:1000, 24868-1-AP, Proteintech) antibodies. ..

    Incubation:

    Article Title: Sequential delivery of sinigrin and dabigatran by an in situ self-stabilizing dynamic hydrogel attenuates intervertebral disc degeneration
    Article Snippet: Prior to SDS-PAGE, protein concentrations were quantified using a BCA Protein Assay Kit (Beyotime, China). .. The membranes were then incubated overnight with anti-GAPDH (1:50 000, AC054, abclone, China), anti-Col2α1(1:500, A19308, abclone, China), anti-Acan (1:1000, A8536, abclone, China), anti-SOX9 (1:1000, A19710, abclone, China), anti-MMP13 (1:1000, A1606, abclone, China), anti-ADAMTS4 (1:500, A2525, abclone, China), anti-iNOS (1:1000, 18985-1-AP, proteintech, China), anti-COX2 (1:1000, 12375-1-AP, proteintech, China), anti-ERK (1:2000, 11257-1-AP, proteintech, China), anti-Phospho-ERK (1:1000, 28733-1-AP, proteintech, China), anti-JNK (1:500, 51153-1-AP, proteintech, China), anti-Phospho-JNK (1:1000, 80024-1-RR, proteintech, China), anti-p38 (1:1000, A4771, abclone, China), anti-Phospho-p38 (1:500, AP1508, abclone, China), anti-p65 (1:5000, A19653, abclone, China), anti-Phospho-p65 (1:500, AP0475, abclone, China), anti-IκBα (1:500, A1187, abclone, China), anti-Phospho-IκBα (1:500, AP0420, abclone, China), anti-AMPK (1:5000, A28094, abclone, China), anti-Phospho-AMPK (1:500, AP0432, abclone, China), The membrane was incubated with HRP-conjugated Goat anti-rabbit IgG (H + L) (1:50 000, AS014, rabbit monoclonal, Abclone, China) and immunoreactive proteins were detected using enhanced chemiluminescence. .. Images were captured using the Bio-Rad ChemiDoc Touch Imaging System, and protein band density was analyzed using ImageJ software.

    Article Title: Dexmedetomidine alleviates sepsis-associated acute kidney injury by inhibiting renal tubular ferroptosis via JNK/MAPK–LCN2 pathway
    Article Snippet: Equal amounts of protein were separated by 10% Tris–Glycine extended stain-free SDS-PAGE gels (Bio-Rad, USA) and transferred onto polyvinylidene difluoride (PVDF) membranes (Roche, USA) using a wet transfer apparatus (Bio-Rad, USA). .. Membranes were blocked with 5% non-fat milk at room temperature for 1.5 h, followed by overnight incubation at 4 °C with the following primary antibodies: Anti-LCN2 (Proteintech, 26991–1-AP, 1:1000) for HK-2 cells, Anti-LCN2 (Abcam, ab216462, 1:1000) for murine renal tissues, Anti-ACSL4 (Abcam, ab155282, 1:20000), Anti-COX2 (Proteintech, 66351–1-Ig, 1:2000), Anti-xCT (Abcam, ab175186, 1:4000), Anti-GPX4 (CST, #52455, 1:1000), Anti-JNK (CST, #9252, 1:1000), Anti-p-JNK (CST, #4671, 1:1000), Anti-ERK (Proteintech, 11257–1-AP, 1:5000), Anti-p-ERK (Proteintech, 28733–1-AP, 1:3000), Anti-p38 (Proteintech, 14064–1-AP, 1:1000), Anti-p-p38 (Proteintech, 28796–1-AP, 1:2000). .. After washing, membranes were incubated with secondary antibodies at room temperature for 1.5 h: Goat anti-rabbit IgG (CST, #7074, 1:3000), Goat anti-mouse IgG (CST, #7076, 1:3000).

    Membrane:

    Article Title: Sequential delivery of sinigrin and dabigatran by an in situ self-stabilizing dynamic hydrogel attenuates intervertebral disc degeneration
    Article Snippet: Prior to SDS-PAGE, protein concentrations were quantified using a BCA Protein Assay Kit (Beyotime, China). .. The membranes were then incubated overnight with anti-GAPDH (1:50 000, AC054, abclone, China), anti-Col2α1(1:500, A19308, abclone, China), anti-Acan (1:1000, A8536, abclone, China), anti-SOX9 (1:1000, A19710, abclone, China), anti-MMP13 (1:1000, A1606, abclone, China), anti-ADAMTS4 (1:500, A2525, abclone, China), anti-iNOS (1:1000, 18985-1-AP, proteintech, China), anti-COX2 (1:1000, 12375-1-AP, proteintech, China), anti-ERK (1:2000, 11257-1-AP, proteintech, China), anti-Phospho-ERK (1:1000, 28733-1-AP, proteintech, China), anti-JNK (1:500, 51153-1-AP, proteintech, China), anti-Phospho-JNK (1:1000, 80024-1-RR, proteintech, China), anti-p38 (1:1000, A4771, abclone, China), anti-Phospho-p38 (1:500, AP1508, abclone, China), anti-p65 (1:5000, A19653, abclone, China), anti-Phospho-p65 (1:500, AP0475, abclone, China), anti-IκBα (1:500, A1187, abclone, China), anti-Phospho-IκBα (1:500, AP0420, abclone, China), anti-AMPK (1:5000, A28094, abclone, China), anti-Phospho-AMPK (1:500, AP0432, abclone, China), The membrane was incubated with HRP-conjugated Goat anti-rabbit IgG (H + L) (1:50 000, AS014, rabbit monoclonal, Abclone, China) and immunoreactive proteins were detected using enhanced chemiluminescence. .. Images were captured using the Bio-Rad ChemiDoc Touch Imaging System, and protein band density was analyzed using ImageJ software.

    Marker:

    Article Title: Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease.
    Article Snippet: An anti-IBA1 primary antibody (ab178846) was acquired from Abcam plc (Cambridge, UK). .. Anti-iNOS (18985-1-AP), anti-COX2 (12375-1-AP), anti-PGAM5 (28445-1-AP), anti-NLRP3 (30109-1-AP), and anti-ASC (83858-3-RR) primary antibodies were purchased from Proteintech (Wuhan, China). anti-Actin (AA128) primary antibody, horseradish peroxidase (HRP)-labeled goat anti-rabbit IgG (H + L) (A0208), HRP-labeled goat anti-mouse IgG (H + L) (A0216) secondary antibodies, and prestained color protein marker (P0068; P0071) were acquired from Beyotime Biotechnology (Shanghai, China). .. Goat Antimouse IgG (H + L) (DyLight 647 conjugate) (BA1151), Goat anti-mouse IgG (H + L) (DyLight 550 conjugate) (BA1133), and Goat anti-rabbit IgG (H + L) (DyLight 550 conjugate) (BA1135) secondary antibodies were obtained from Boster Biotechnology (Wuhan, China).

    Article Title: Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease
    Article Snippet: An anti‐IBA1 primary antibody (ab178846) was acquired from Abcam plc (Cambridge, UK). .. Anti‐iNOS (18985‐1‐AP), anti‐COX2 (12375‐1‐AP), anti‐PGAM5 (28445‐1‐AP), anti‐NLRP3 (30109‐1‐AP), and anti‐ASC (83858‐3‐RR) primary antibodies were purchased from Proteintech (Wuhan, China). anti‐Actin (AA128) primary antibody, horseradish peroxidase (HRP)‐labeled goat anti‐rabbit IgG (H+L) (A0208), HRP‐labeled goat anti‐mouse IgG (H+L) (A0216) secondary antibodies, and prestained color protein marker (P0068; P0071) were acquired from Beyotime Biotechnology (Shanghai, China). .. Goat Anti‐mouse IgG (H+L) (DyLight 647 conjugate) (BA1151), Goat anti‐mouse IgG (H+L) (DyLight 550 conjugate) (BA1133), and Goat anti‐rabbit IgG (H+L) (DyLight 550 conjugate) (BA1135) secondary antibodies were obtained from Boster Biotechnology (Wuhan, China).



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    Image Search Results


    Therapeutic effect of LAC in the monoiodoacetate mouse model. (A) H&E staining of the joint from MIA mice after different treatments. (B) Quantitative analysis of the synovitis score. (C) Representative images of SO&FG‐stained knee joint sections from MIA mice with different treatments. (D) The severity of OA‐like lesions was analyzed using the OARSI scoring system. (E) Immunofluorescence imaging of iNOS (red)/CD206 (green) within the knee joints of mice with different treatments. (F) Corresponding quantification of the MFI of CD206 in the synovium of mice with different treatments. (G) Immunohistochemical staining of COX‐2, TNF‐α, and TRAP in the knee joints of mice with different treatments. (H,I) Quantification of the relative density of COX‐2 + (H) and TNF‐α + (I) cells in the knee joints of mice with different treatments. n = 5 in B and D, and n = 3 in F, H, and I, mean ± SD. The significant differences are determined by one‐way ANOVA analysis with Tukey's multiple comparison test. ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns stands for no significant difference.

    Journal: Exploration

    Article Title: Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage

    doi: 10.1002/exp2.70233

    Figure Lengend Snippet: Therapeutic effect of LAC in the monoiodoacetate mouse model. (A) H&E staining of the joint from MIA mice after different treatments. (B) Quantitative analysis of the synovitis score. (C) Representative images of SO&FG‐stained knee joint sections from MIA mice with different treatments. (D) The severity of OA‐like lesions was analyzed using the OARSI scoring system. (E) Immunofluorescence imaging of iNOS (red)/CD206 (green) within the knee joints of mice with different treatments. (F) Corresponding quantification of the MFI of CD206 in the synovium of mice with different treatments. (G) Immunohistochemical staining of COX‐2, TNF‐α, and TRAP in the knee joints of mice with different treatments. (H,I) Quantification of the relative density of COX‐2 + (H) and TNF‐α + (I) cells in the knee joints of mice with different treatments. n = 5 in B and D, and n = 3 in F, H, and I, mean ± SD. The significant differences are determined by one‐way ANOVA analysis with Tukey's multiple comparison test. ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns stands for no significant difference.

    Article Snippet: Proteins in equivalent amounts were then separated on a 10% sodium dodecyl sulfate‐polyacrylamide gel electrophoresis (SDS‐PAGE) and transferred to the PVDF membrane, followed by blocking in TBS‐T solution containing 5% skim milk for 1 h. Subsequently, the membrane was incubated with primary antibody against COX‐2 (66351‐1‐Ig, Proteintech), iNOS (80517‐1‐RR, Proteintech), and CD206 (60143‐1‐Ig, Proteintech) overnight at 4°C.

    Techniques: Staining, Analysis, Immunofluorescence, Imaging, Immunohistochemical staining, Comparison

    Upregulation of proteins associated with uterine TLR2/4–NF-κB–COX-2 inflammatory signaling in rats with Gardnerella vaginalis -associated bacterial vaginosis. (A) Relative protein abundance of Toll-like receptor 2 (TLR2), TLR4, phospho-NF-κB p65 at serine 536 (pS536-p65) and cyclooxygenase-2 (COX-2) in uterine tissues. Data are presented as the means ( X ¯ ) ± standard error of the mean (SEM); n = 3 independent uterine tissue samples per group. Statistical significance was determined using Student’s t-tests . Complete densitometric values are provided in <xref ref-type=Supplementary Table 11 . (B) Representative Western blot images. Protein levels were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Original uncropped Western blot images are provided in Supplementary Figure 1 . " width="100%" height="100%">

    Journal: Frontiers in Immunology

    Article Title: Inflammatory landscape of Gardnerella vaginalis -associated bacterial vaginosis in rats: an integrated multi-omics analysis

    doi: 10.3389/fimmu.2026.1914434

    Figure Lengend Snippet: Upregulation of proteins associated with uterine TLR2/4–NF-κB–COX-2 inflammatory signaling in rats with Gardnerella vaginalis -associated bacterial vaginosis. (A) Relative protein abundance of Toll-like receptor 2 (TLR2), TLR4, phospho-NF-κB p65 at serine 536 (pS536-p65) and cyclooxygenase-2 (COX-2) in uterine tissues. Data are presented as the means ( X ¯ ) ± standard error of the mean (SEM); n = 3 independent uterine tissue samples per group. Statistical significance was determined using Student’s t-tests . Complete densitometric values are provided in Supplementary Table 11 . (B) Representative Western blot images. Protein levels were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Original uncropped Western blot images are provided in Supplementary Figure 1 .

    Article Snippet: After blocking with a rapid blocking buffer (Epizyme, Shanghai, China), the blots were incubated overnight at 4 °C with the following primary antibodies: TLR2 (Abcam, Cambridge, UK; dilution 1:1000), TLR4 (Proteintech, Hubei, China; dilution 1:1000), phospho-NF-κB p65 at serine 536 (pS536-p65; Proteintech; dilution 1:2000), cyclooxygenase-2 (COX-2; Proteintech; dilution 1:1000), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH; Proteintech; dilution 1:10000).

    Techniques: Quantitative Proteomics, Tissue, Western Blot

    PTX/Pt@RGD induces oxidative stress, mitochondrial dysfunction, DNA damage, and apoptosis in A549 cells. (A) PTX/Pt@RGD induced ROS generation in A549 cells. Representative fluorescence images of A549 cells stained with DCFH-DA after 24-h treatment with the indicated formulations (green fluorescence indicates ROS levels) (magnification: 20×). Quantitative analysis of relative DCFH-DA fluorescence intensity. Data are presented as the mean ± SD from three independent experiments (n=3). Statistical significance was determined via one-way ANOVA followed by the Tukey post hoc test. (B) PTX/Pt@RGD induced loss of mitochondrial membrane potential in A549 cells. Representative fluorescence images of A549 cells stained with JC-1 after 24-h treatment with the indicated formulations. JC-1 monomer emitted green fluorescence (Ex/Em = 490/530 nm), and JC-1 aggregates emitted red fluorescence (Ex/Em =490/590 nm) (magnification: ×20). Quantitative analysis of the red:green fluorescence intensity ratio. Data are presented as the mean ± SD from three independent experiments (n=3). Statistical significance was determined via one-way ANOVA followed by the Tukey post hoc test. (C) PTX/Pt@RGD induced DNA damage in A549 cells (γ-H2AX immunofluorescence). Representative immunofluorescence images of A549 cells stained with anti-γ-H2AX antibody (green) and DAPI (blue) after 24-h treatment with the indicated formulations (magnification: ×20). Quantitative analysis of relative DNA damage index (γ-H2AX/DAPI mean fluorescence intensity). Data are presented as the mean ± SD from three independent experiments (n=3). Statistical significance was determined via one-way ANOVA followed by the Tukey post hoc test. (D) Western blot analysis of apoptosis- and inflammation-related proteins in A549 cells after different treatments. Protein expression of Bax, Bcl-2, Caspase-9, and COX-2 was detected by Western blotting with β-actin as the loading control. Relative protein levels were quantified and normalized to β-actin. Data are shown as the mean ± SD (n=3). (E) PTX/Pt@RGD induced apoptosis in A549 cells. Flow cytometry analysis of apoptosis in A549 cells after treatment with control, PTX, Pt, PTX/Pt, or PTX/Pt@RGD. The bar graph shows the quantitative percentage of apoptotic cells. Data are presented as mean ± SD (n=3). ns, not significant; *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 compared to the control group. ANOVA, analysis of variance; Ex/Em, excitation/emission; Pt, cisplatin; PTX, paclitaxel; RGD, arginine-glycine-aspartic acid; ROS, reactive oxygen species; SD, standard deviation.

    Journal: Translational Lung Cancer Research

    Article Title: Targeted dual-responsive nanocapsules for synergistic cisplatin and paclitaxel prodrug delivery in the treatment of lung cancer

    doi: 10.21037/tlcr-2026-0967

    Figure Lengend Snippet: PTX/Pt@RGD induces oxidative stress, mitochondrial dysfunction, DNA damage, and apoptosis in A549 cells. (A) PTX/Pt@RGD induced ROS generation in A549 cells. Representative fluorescence images of A549 cells stained with DCFH-DA after 24-h treatment with the indicated formulations (green fluorescence indicates ROS levels) (magnification: 20×). Quantitative analysis of relative DCFH-DA fluorescence intensity. Data are presented as the mean ± SD from three independent experiments (n=3). Statistical significance was determined via one-way ANOVA followed by the Tukey post hoc test. (B) PTX/Pt@RGD induced loss of mitochondrial membrane potential in A549 cells. Representative fluorescence images of A549 cells stained with JC-1 after 24-h treatment with the indicated formulations. JC-1 monomer emitted green fluorescence (Ex/Em = 490/530 nm), and JC-1 aggregates emitted red fluorescence (Ex/Em =490/590 nm) (magnification: ×20). Quantitative analysis of the red:green fluorescence intensity ratio. Data are presented as the mean ± SD from three independent experiments (n=3). Statistical significance was determined via one-way ANOVA followed by the Tukey post hoc test. (C) PTX/Pt@RGD induced DNA damage in A549 cells (γ-H2AX immunofluorescence). Representative immunofluorescence images of A549 cells stained with anti-γ-H2AX antibody (green) and DAPI (blue) after 24-h treatment with the indicated formulations (magnification: ×20). Quantitative analysis of relative DNA damage index (γ-H2AX/DAPI mean fluorescence intensity). Data are presented as the mean ± SD from three independent experiments (n=3). Statistical significance was determined via one-way ANOVA followed by the Tukey post hoc test. (D) Western blot analysis of apoptosis- and inflammation-related proteins in A549 cells after different treatments. Protein expression of Bax, Bcl-2, Caspase-9, and COX-2 was detected by Western blotting with β-actin as the loading control. Relative protein levels were quantified and normalized to β-actin. Data are shown as the mean ± SD (n=3). (E) PTX/Pt@RGD induced apoptosis in A549 cells. Flow cytometry analysis of apoptosis in A549 cells after treatment with control, PTX, Pt, PTX/Pt, or PTX/Pt@RGD. The bar graph shows the quantitative percentage of apoptotic cells. Data are presented as mean ± SD (n=3). ns, not significant; *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 compared to the control group. ANOVA, analysis of variance; Ex/Em, excitation/emission; Pt, cisplatin; PTX, paclitaxel; RGD, arginine-glycine-aspartic acid; ROS, reactive oxygen species; SD, standard deviation.

    Article Snippet: Antibodies included primary antibodies against CD31 [cat. no. 11265-1-P; rabbit polyclonal antibody; Western blotting (WB) 1:500; immunohistochemistry (IHC) 1:100; Proteintech, Rosemont, IL, USA], Ki-67 (cat. no. 27309-1-AP; rabbit polyclonal antibody; IHC 1:200; Proteintech), PCNA (cat. no. 10205-2-AP; rabbit polyclonal antibody; IHC 1:500; Proteintech), Bcl-2 (cat. no. 12789-1-AP; WB 1:1,000; Proteintech), Caspase-9 (cat. no. 10380-1-AP; WB 1:1,000; Proteintech), Bax (cat. no. 50599-2-Ig; WB 1:2,000; Proteintech), COX-2 (cat. no. 12375-1-AP, WB 1:1000; Proteintech), and β-actin (cat. no. 66009-1-Ig; WB 1:5,000; internal control), as well as horseradish peroxidase (HRP)-conjugated goat anti-rabbit secondary antibody (cat. no. SA00001-2; WB 1:5,000; Proteintech).

    Techniques: Fluorescence, Staining, Analysis, Membrane, Immunofluorescence, Western Blot, Expressing, Control, Flow Cytometry, Standard Deviation

    QJSB alleviates inflammation in DSS-induced UC mice in vivo ( n = 6). (A) , (B) , (C) and (D) Levels of MPO, IL-6, IL-1β, and TNF-α in the colon; (E) , (F) and (G) serum levels of IL-1β, IL-6, and TNF-α; (H) levels of LPS in feces. (I) protein blots for iNOS and COX-2; (J) Relative expression levels of iNOS; (K) relative expression levels of COX-2; (L) correlation analysis between inflammatory mediators and colon-specific metabolites. (### p < 0.001, ## p < 0.01, # p vs. Control; * p < 0.05, ** p < 0.01, *** p < 0.001vs. Model).

    Journal: Frontiers in Microbiology

    Article Title: Qijiao Shengbai capsule ameliorates ulcerative colitis in mice by modulating gut microbiota and protecting the intestinal barrier, associated with suppression of the TLR4/MyD88/NF-κB pathway

    doi: 10.3389/fmicb.2026.1875650

    Figure Lengend Snippet: QJSB alleviates inflammation in DSS-induced UC mice in vivo ( n = 6). (A) , (B) , (C) and (D) Levels of MPO, IL-6, IL-1β, and TNF-α in the colon; (E) , (F) and (G) serum levels of IL-1β, IL-6, and TNF-α; (H) levels of LPS in feces. (I) protein blots for iNOS and COX-2; (J) Relative expression levels of iNOS; (K) relative expression levels of COX-2; (L) correlation analysis between inflammatory mediators and colon-specific metabolites. (### p < 0.001, ## p < 0.01, # p vs. Control; * p < 0.05, ** p < 0.01, *** p < 0.001vs. Model).

    Article Snippet: TLR4, MyD88, IκBα, p-IκBα, NF-κB p65, NF-κB p-p65, iNOS, and COX-2 antibodies were obtained from Proteintech (Wuhan, China).

    Techniques: In Vivo, Expressing, Analysis, Control